With existing water resources strained by growth and drought and a need to maintain environmental flows, U.S. water utilities in some of the country's most populous coastal states, including Florida, Texas, and California, have increasingly explored seawater reverse osmosis (SWRO) to generate a new source of drought-proof, reliable, untapped water. To better understand issues associated with integrating desalinated seawater into existing systems, the Metropolitan Water District of Southern California, Los Angeles, California, investigated and assessed integration practices at 10 prominent SWRO facilities around the world. This article focuses on strategic practices for integrating desalinated seawater and important lessons learned from the respondents. The rationale for selecting the targeted plants and the survey methodology are also discussed.